Serum immune-activation potency and response to anti-TNF-α therapy in Crohn's disease

Figure 1 Patient serum withdrawn before anti-tumor necrosis factor-α therapy induced forkhead transcription factor 3 (A) and glucocorticoid-induced tumour necrosis factor receptor (B) specific mRNA expression (relative units) in activated target cells that correlated negatively with pre-treatment Crohn's disease endoscopic index of severity. [points; forkhead transcription factor 3 (FOXP3) r = -0.621, P = 0.013; glucocorticoid-induced tumour necrosis factor receptor (GITR) r = -0.625, P = 0.013]. Patients who had no decrease in Crohn's disease endoscopic index of severity (CDEIS) during therapy are marked with star.