Toll-like receptor 9 gene mutations and polymorphisms in Japanese ulcerative colitis patients

doi:10.3748/wjg.v16.i46.5815

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2010; 16(46): 5815-5821
Published online Dec 14, 2010. doi: 10.3748/wjg.v16.i46.5815

Table 3 Allele frequencies in ulcerative colitis cases and disease-free controls for Toll-like receptor 9 single nucleotide polymorphisms at -1486, 1174, 2848

SNP¹	Allele	UC (n = 48)	Controls (n = 47)	dbSNP²	JSNP³
-1486	T/C	0.344/0.656^a	0.532/0.468	0.647/0.353	ND
1174	A/G	0.344/0.656^a	0.532/0.468	0.512/0.488	0.517/0.483
2848	G/A	0.354/0.646^a	0.543/0.457	0.481/0.519	0.517/0.483
					^aP = 0.013

¹Positions were calculated taking the A of the Toll-like receptor 9 (TLR9) ATG start codon as position 1 based on Genbank Accession No. NM_017442;

²dbSNP public database: http://www.ncbi.nlm.nih.gov/SNP.

³JSNP is a database of Japanese SNPs: http://snp.ims.u-tokyo.ac.jp/index_ja.html;

^aP value by Fisher’s Exact test, cases vs controls. SNP: Single nucleotide polymorphisms; UC: Ulcerative colitis; ND: No data.

Citation: Fuse K, Katakura K, Sakamoto N, Ohira H. Toll-like receptor 9 gene mutations and polymorphisms in Japanese ulcerative colitis patients. World J Gastroenterol 2010; 16(46): 5815-5821
URL: https://www.wjgnet.com/1007-9327/full/v16/i46/5815.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i46.5815