Genetic variations in the SMAD4 gene and gastric cancer susceptibility

Table 3 Genotype distributions of the SMAD4 tSNPs in gastric cancer cases and controls and risk estimates n (%)

SNP No.	SNP ID	Genotypes	Cases (n = 322)	Controls (n = 351)1	P value (2df)2	Crude OR (95% CI)	Adjusted OR (95% CI)3
1	rs12958604	AA	99 (30.8)	106 (30.5)	0.961	1.00	1.00
		AG	155 (48.1)	171 (49.1)		0.97 (0.68-1.38)	0.98 (0.69-1.39)
		GG	68 (21.1)	71 (20.4)		1.03 (0.67-1.59)	1.01 (0.66-1.56)
2	rs10502913	GG	164 (51.0)	162 (46.4)	0.505	1.00	1.00
		GA	136 (42.2)	161 (46.1)		0.83 (0.61-1.14)	0.86 (0.63-1.18)
		AA	22 (6.8)	26 (7.5)		0.84 (0.46-1.54)	0.81 (0.44-1.49)
3	rs17663887	TT	307 (95.3)	311 (88.6)	< 0.001	1.00	1.00
		TC	15 (4.7)	40 (11.4)		0.38 (0.21-0.70)	0.38 (0.21-0.71)
4	rs9304407	GG	85 (26.4)	112 (31.9)	0.291	1.00	1.00
		GC	179 (55.6)	181 (51.6)		1.30 (0.92-1.85)	1.32 (0.93-1.87)
		CC	58 (18.0)	58 (16.5)		1.32 (0.83-2.09)	1.29 (0.81-2.05)
5	rs12456284	AA	149 (46.3)	143 (40.7)	0.003	1.00	1.00
		AG	160 (49.7)	170 (48.4)		0.90 (0.66-1.24)	0.90 (0.66-1.24)
		GG	13 (4.0)	38 (10.8)		0.33 (0.17-0.64)	0.31 (0.16-0.60)

¹No. of subjects in controls (n = 348 for SNP1, n = 349 for SNP2) were less than the total number (n = 351) because some DNA could not be genotyped;

²Two-sided χ² test for the frequency distribution;

³Adjusted for age, sex, smoking status, and alcohol use. SNP: Single nucleotide polymorphism; OR: Odds ratio; CI: Confidence interval.