Genetic variations in the SMAD4 gene and gastric cancer susceptibility

Table 1 Information on five genotyped tagging single nucleotide polymorphisms in the SMAD4 gene

SNP No.	SNP ID	Location	MAF			P2	P for HWE3	Genotyping rate (%)
			Database1	Cases	Controls
1	rs12958604	Intron 2	0.446	0.452	0.450	0.956	0.893	99.1
2	rs10502913	Intron 2	0.363	0.280	0.305	0.308	0.117	99.4
3	rs17663887	Intron 9	0.056	0.023	0.057	< 0.001	0.258	100.0
4	rs9304407	Intron 11	0.411	0.458	0.423	0.206	0.291	100.0
5	rs12456284	3’-UTR	0.405	0.289	0.350	0.017	0.231	100.0

¹Minor allele frequency (MAF) for Han Chinese in Beijing (CHB) population in the HapMap database (http://www.hapmap.org);

²P value for the allele distribution difference between the cases and controls;

³Hardy-Weinberg equilibrium (HWE) P value in the control group. SNP: Single nucleotide polymorphism; 3’-UTR: 3’-untranslated region.