Fresh frozen plasma transfusion does not affect outcomes following hepatic resection for hepatocellular carcinoma

Table 1 Comparison of perioperative characteristics between Group A (1983-1993) and Group B (1998-2006), and between Group B1 and Group B2 n (%)

	Group A (1983-1993) (n = 204)	Group B (1998-2006) (n = 297)	P-value	Group B		P-value
				Group B1 (n = 22)	Group B2 (n = 275)
Age (yr)
< 60	114 (55.9)	207 (69.7)	0.0015	9 (40.9)	81 (29.5)	NS
≥ 60	90 (44.1)	90 (30.3)		13 (59.1)	194 (70.5)
Gender
Male	178 (87.3)	235 (79.1)	0.0188	20 (90.9)	215 (78.2)	NS
Female	26 (12.7)	62 (20.9)		2 (9.1)	60 (21.8)
Child-Pugh
A	187 (91.7)	251 (84.5)	0.0176	17 (77.3)	234 (85.1)	NS
B	17 (8.3)	46 (15.5)		5 (22.7)	41 (14.9)
Viral infection
HBV (+)	40/201 (19.9)	56 (18.9)	NS	4 (18.2)	52 (18.9)	NS
HCV (+)	47/78 (60.3)	177 (59.6)	NS	11 (40.9)	166 (61.1)	NS
Surgical procedure
≤ Hr1	171 (83.8)	241 (81.1)	NS	14 (63.6)	227 (82.5)	0.0436
≥ Hr2	33 (16.2)	56 (18.9)		8 (36.4)	48 (17.5)
Intraoperative blood loss (mL)
< 2000	133 (65.2)	247 (83.2)	< 0.0001	1 (4.5)	246 (89.5)	< 0.0001
≥ 2000	71 (34.8)	50 (16.8)		21 (95.5)	29 (10.5)
Use of FFP
(-)	0 (0)	275 (92.6)	< 0.0001
(+)	204 (100.0)	22 (7.4)
Mortality	8 (3.9)	0 (0)	0.0007	0 (0)	0 (0)	--
Morbidity	55 (27.0)	73 (24.6)	NS	9 (40.9)	64 (23.2)	NS

HBV: Hepatitis B virus; HCV: Hepatitis C virus; ≤ Hr1: Partial resection, subsegmentectomy, and segmentectomy of the liver; ≥ Hr2: Bisegmentectomy or more; FFP: Fresh frozen plasma; NS: Not significant.