Chronic stress sensitizes rats to pancreatitis induced by cerulein: Role of TNF-α

Table 9 Inflammatory parameters in lung tissue (mean ± SE)

Group	TNF-α (ng/mg DNA)	MPO (U/mg DNA)	NF-κB (p65) (μg/mg DNA)	NF-κB (p50) (μg/mg DNA)
Stress (-)
Veh	BD	0.00 ± 0.00	23 ± 2	0.27 ± 0.02
Cer	BD	0.00 ± 0.00	24 ± 2	0.30 ± 0.02
Anti-TNF-α + Cer	BD	0.00 ± 0.00	24 ± 3	0.29 ± 0.03
Stress (+)
Veh	1.3 ± 0.1a	0.89 ± 0.12	43 ± 5	0.51 ± 0.03
Cer	4.2 ± 0.3a	12.10 ± 0.56a	251 ± 19a	2.92 ± 0.28a
Anti-TNF-α + Cer	1.8 ± 0.2c	5.04 ± 0.29c	107 ± 9c	1.13 ± 0.11c

^aP < 0.05 vs control-vehicle Stress (-) group;

^cP < 0.05 vs Stress (+) plus Cer group. TNF-α: Tumor necrosis factor-α; MPO: Myeloperoxidase; NF-κB: Nuclear factor-κB.