Chronic stress sensitizes rats to pancreatitis induced by cerulein: Role of TNF-α

Table 7 Energy metabolism in pancreatic tissue (mean ± SE)

Group	ATP (μmol/mg protein)	ATP loss (%)	ADP/ATP ratio
Stress (-)
Veh	9.1 ± 0.4	0.0 ± 4.4	0.32 ± 0.04
Cer	6.8 ± 0.5	25.3 ± 5.5	0.38 ± 0.05
Anti-TNF-α + Cer	6.9 ± 0.6	24.2 ± 6.6	0.36 ± 0.04
Stress (+)
Veh	7.3 ± 0.5	19.8 ± 5.5	0.40 ± 0.06
Cer	2.6 ± 0.4a	71.4 ± 4.4a	0.94 ± 0.11a
Anti-TNF-α + Cer	5.3 ± 0.3c	41.8 ± 3.3c	0.63 ± 0.07c

^aP < 0.05 vs control-vehicle Stress (-) group;

^cP < 0.05 vs Stress (+) plus Cer group. TNF-α: Tumor necrosis factor-α.