Chronic stress sensitizes rats to pancreatitis induced by cerulein: Role of TNF-α

Table 4 Inflammatory parameters in blood (mean ± SE)

Group	Leukocytes (ng/mL)	CRP (mg/dL)	HSP-72 (pg/mL)	IL-6 (pg/mL)	IL-10 (pg/mL)	MIP-1α (pg/mL)
Stress (-)
Veh	5900 ± 240	0.0 ± 0.0	558 ± 27	BD	BD	7 ± 1
Cer	6111 ± 248	0.0 ± 0.0	866 ± 32	BD	BD	9 ± 1
Anti-TNF-α + Cer	6005 ± 244	0.0 ± 0.0	817 ± 49	BD	BD	8 ± 1
Stress (+)
Veh	7139 ± 250	1.5 ± 0.2a	899 ± 63	66 ± 6a	75 ± 5a	54 ± 4a
Cer	21 222 ± 976a	24.9 ± 1.3a	2648 ± 159a	1115 ± 54a	1404 ± 148a	318 ± 23a
Anti-TNF-α + Cer	12 733 ± 586c	12.4 ± 0.8c	1805 ± 112c	417 ± 38c	596 ± 68c	127 ± 11b

^aP < 0.05 vs control-vehicle Stress (-) group;

^cP < 0.05 vs Stress (+) plus Cer group. CRP: C-reactive protein; HSP: Heat shock protein; IL: Interleukin; MIP-1α: Macrophage inflammatory protein-1α; TNF-α: Tumor necrosis factor-α; BD: Below detection limit.