Chronic stress sensitizes rats to pancreatitis induced by cerulein: Role of TNF-α

Table 2 Histopathological score in pancreatic tissue (mean ± SE)

Group	Edema	Hemorrhage	Leukocyte infiltrate	Necrosis
Stress (-)
Veh	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
Cer	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
Anti-TNF-α + Cer	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
Stress (+)
Veh	0.49 ± 0.06	0.00 ± 0.00	0.39 ± 0.05	0.00 ± 0.00
Cer	1.28 ± 0.11a	3.11 ± 0.17a	2.19 ± 0.10a	3.12 ± 0.15a
Anti-TNF-α + Cer	2.19 ± 0.17c	1.21 ± 0.17c	1.32 ± 0.10c	1.37 ± 0.19c

^aP < 0.05 vs control-vehicle Stress (-) group;

^cP < 0.05 vs Stress (+) plus Cer group. TNF-α: Tumor necrosis factor-α.