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©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 28, 2010; 16(44): 5543-5554
Published online Nov 28, 2010. doi: 10.3748/wjg.v16.i44.5543
Published online Nov 28, 2010. doi: 10.3748/wjg.v16.i44.5543
Table 2 Results of different randomized trials comparing chemotherapy with chemotherapy plus rituximab in previously untreated patients with follicular lymphoma
Study | No. of patients, pathological types, staging | Median age (yr) | Complete response rate | End point | ||||
Median progression-free survival | Event-free survival | Median response duration | Time to treatment failure | Overall survival | ||||
CVP[40] | n = 321, FL, Stage II-IV | 52 | P < 0.0001b | P < 0.0001b | P < 0.001b | P = 0.029a | ||
R-CVP | n = 162 | Unknown | 41% | 34 mo | Prolonged than CVP alone (lower relapse rate than CVP alone) | Prolonged than CVP alone | 83% (at 4 yr) | |
CVP | n = 159 | Unknown | 11% | 15 mo | 77% (at 4 yr) | |||
GLSG[38,39] | n = 428, FL, Stage III or IV(advanced stage) | 55 | P > 0.05 (not significant) | P = 0.001b | P < 0.001b | P = 0.016a | ||
R-CHOP | n = 223 | 54 | 20% | Not reached | Lower relapse rate than CHOP alone | 28/233 (12.0%) | 95% (at 2 yr) | |
CHOP | n = 205 | 57 | 17% | 31 mo | 61/205 (29.8%) | 90% (at 2 yr) | ||
FL2000[41] | n = 358, FL, 89% > stage II | 61 | P = 0.001b | P = 0.001b | P = 0.012a | P > 0.05 (not significant) | ||
R-CHVP/IFN | n = 175 | Unknown | 67% (at 18 mo) | Not reached | 53% (at 5 yr) | 64% (at 4 yr) | 84% (at 5 yr) | |
CHVP/IFN | n = 183 | Unknown | 50% (at 18 mo) | 35 mo | 37% (at 5 yr) | 44% (at 4 yr) | 79% (at 5 yr) | |
OSHO[42] | n = 201, FL, Stage II and IV | 59 | P = 0.0004b | P < 0.0001b | P < 0.0001b | P < 0.0001b | P = 0.0096b | |
R-MCP | n = 105 | 60 | 52/105 (50%) | Not reached | Not reached | Not reached | 87% (at 4 yr) | |
MCP | n = 96 | 57 | 25/96 (25%) | 28.8 mo | 26 mo | 35 mo | 74% (at 4 yr) |
- Citation: Watanabe T. Treatment strategies for nodal and gastrointestinal follicular lymphoma: Current status and future development. World J Gastroenterol 2010; 16(44): 5543-5554
- URL: https://www.wjgnet.com/1007-9327/full/v16/i44/5543.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i44.5543