Specific intronic p53 mutation in esophageal squamous cell carcinoma in Southern Thailand

Figure 1 Single-strand conformation polymorphism analysis and direct sequencing of p53. A: Single-strand conformation polymorphism of p53, exons 5-8 in representative positive cases (+), which showed anomalous bands compared to normal bands in negative cases (-); B: Sequencing chromatograms that represent case E355 (left), which shows TGC-> TTC mutation at codon 176 (arrow) and case E106 (right), which shows CGG-> CAG at codon 248 (arrow).