MK615 decreases RAGE expression and inhibits TAGE-induced proliferation in hepatocellular carcinoma cells

Figure 7 Changes in percentage inhibition resulting from pre- or post-treatment with MK615. A: Cells were cultured for 24 h with MK615, and then advanced glycation end-products (AGEs) were added, followed by culture for a further 24 h. The proliferative effect of Glycer-AGE was abrogated by pretreatment with MK615 in both HuH7 and HepG2 cells; B: Cells were cultured for 24 h with AGEs, and then MK615 were added, followed by culture for a further 24 h. The proliferative effect elicited by Glycer-AGE was still evident, but was reduced. ss: Statistically significant.