Total salvianolic acid improves ischemia-reperfusion-induced microcirculatory disturbance in rat mesentery

Figure 4 The effect of pre-treatment and post-treatment of total salvianolic acid on ischemia-reperfusion-induced albumin leakage from rat mesenteric venule. A: Representative images for the effect of pre-treatment and post-treatment with total salvianolic acid (TSA) on fluorescein isothiocyanate-labeled albumin leakage from mesentery venule. a1-a3: Fluorescence images of rat mesentery of Sham group at baseline, 10 and 60 min, respectively. b1-b3: Fluorescence images of rat mesentery of TSA group at baseline, 10 and 60 min, respectively. c1-c3: Fluorescence images of rat mesentery of ischemia-reperfusion (I/R) group at baseline, 10 and 60 min, respectively. d1-d3: Fluorescence images of rat mesentery of TSA + I/R group at baseline, 10 and 60 min, respectively. e1-e3: Fluorescence images of rat mesentery of I/R + TSA group at baseline, 10 and 60 min, respectively. V: Rat mesenteric venule; B: Times course of changes in the albumin leakage from mesentery venules. Sham: Sham group; TSA: TSA group; I/R: I/R group; TSA + I/R: TSA plus I/R group; I/R + TSA: I/R plus TSA group. Data was expressed as mean ± SE of six animals. ^aP < 0.05 vs sham group; ^cP < 0.05 vs I/R alone.