Specific intronic p53 mutation in esophageal squamous cell carcinoma in Southern Thailand

Table 3 p53 mutations in esophageal squamous cell carcinoma patients from Songkhla, Southern Thailand

Case ID	Age (yr)/sex	Exon	Codon	Nucleotide change	AA change	Exposure
						Smoke	Alcohol	Betel
E111	60/M	5	130-131	3 bp deletion	Frameshift	Yes	Yes	Yes
E303	73/M	5	134-137	10 bp deletion	Frameshift	-	-	-
E006	63/M	5	156	CGC -> CCC	Arg -> Pro	Yes	Yes	No
E271	57/M	5	158	CGC -> CTC	Arg -> Leu	Yes	Yes	No
E072	58/F	5	159	GCC -> CCC	Ala -> Pro	Yes	Yes	Yes
E200	60/F	5	161	GCC -> ACC	Ala -> Thr	Yes	Yes	Yes
E397	56/M	5	167	CAG -> CGG	Gln -> Arg	Yes	Yes	No
E379	66/M	5	168	CAC -> CTC	His -> Leu	Yes	Yes	No
E355	61/M	5	176	TGC -> TTC	Cys -> Phe	Yes	No	Yes
E014	77/M	5	176	TGC -> TAC	Cys -> Tyr	No	Yes	Yes
E022	46/M	5	184	GAT -> AAT	Asp -> Asn	Yes	Yes	Yes
E464	68/M	6	190	CCT -> CTT	Pro -> Leu	Yes	Yes	No
E259	60/M	7	228-232	21 bp deletion	Frameshift	Yes	Yes	No
E320	72/M	7	234	TAC -> TGC	Tyr -> Cys	No	Yes	Yes
E264	52/M	7	238	TGT -> TAT	Cys -> Tyr	Yes	Yes	No
E446	58/M	7	245	GGC -> CGC	Gly -> Arg	Yes	Yes	No
E106	56/M	7	248	CGG -> CAG (CpG site)	Arg -> Gln	Yes	Yes	No
E298	79/F	7	248	CGG -> TGG (CpG site)	Arg -> Trp	Yes	No	Yes
E294	52/M	7	248	CGG -> TGG (CpG site)	Arg -> Trp	Yes	Yes	No
E419	54/M	7	248	CGG -> TGG (CpG site)	Arg -> Trp	Yes	Yes	No
E022	53/M	7	249	AGG -> ATG	Arg -> Met	Yes	Yes	No
E012	74/M	8	266	GGA -> TGA	Gly -> Ter (end)	Yes	Yes	No
E231	54/M	8	272	GTG -> TAG	Val -> Ter (end)	Yes	Yes	Yes
E455	46/M	8	272	GTG -> ATG	Val -> Met	No	Yes	Yes
E449	47/M	8	278	CCT -> TCT	Pro -> Ser	No	Yes	Yes
E002	53/M	8	279	GGG -> GAG	Gly -> Glu	Yes	Yes	-
E027	54/M	8	280	AGA -> AGT	Arg -> Ser	Yes	Yes	No
E444	79/M	8	283	CGC -> CCC	Arg -> Pro	No	Yes	No
E387	74/F	8	286	GAA -> CAA	Glu -> Gln	Yes	Yes	No
E146	62/M	8	287	GAG -> TAG	Glu -> Ter (end)	Yes	Yes	No
E181	58/F	8	287	GAG -> TAG	Glu -> Ter (end)	No	No	No
E408	58/F	8	296	CAC -> CTC	His -> Leu	No	No	No
E462	74/M	Exon-intron 6		21 bp deletion	Affect splice site	Yes	Yes	No
E023	51/F	Intron 5		TGAGC -> TCTGC	-	No	No	Yes
E158	61/M	Intron 6		GGGG -> GGCG	-	Yes	Yes	Occ
E169	53/M	Intron 6		GGGG -> GGCG	-	Yes	Yes	No
E189	60/M	Intron 6		GGGG -> GGCG	-	Yes	Yes	Yes
E199	48/M	Intron 6		GGGG -> GGCG	-	Yes	Yes	Yes
E240	61/M	Intron 6		GGGG -> GGCG	-	Yes	Yes	-
E302	41/M	Intron 6		GGGG -> GGCG	-	Yes	Yes	Occ
E329	63/M	Intron 6		GGGG -> GGCG	-	Yes	Yes	Yes
E435	45/M	Intron 6		GGGG -> GGCG	-	Yes	Yes	No
E409	56/M	Intron 8		ACGAG -> ACTAG	-	Yes	Yes	Yes

Occ: Occasional.