Smad7 dependent expression signature highlights BMP2 and HK2 signaling in HSC transdifferentiation

Figure 1 Genes whose expression levels were changed (n = 100) after overexpression of Smad7 in hepatic stellate cells are matched to 8 gene ontology annotations using GoMiner[13]. Left part: Percentage of genes matching to the given gene ontology. Note the total percentage is greater than 100% as the same regulated genes can be assigned to different annotations; Right part: Bar diagram shows number of upregulated (grey bars) and downregulated (black bars) genes matching to the given gene ontology (unknown = percentage/number of genes without annotation, other = percentage/number of genes which are not assignable to the given annotations). A: GO group: biological process; B: GO group: molecular function.