Prognostic relevance of β-catenin expression in T2-3N0M0 esophageal squamous cell carcinoma

Table 3 Univariate and multivariate analysis of overall survival rate of esophageal squamous cell carcinoma patients with Cox proportional hazards model

Variable	Univariate analysis			Multivariate analysis
	Hazard ratio	95% CI	P-value	Hazard ratio	95% CI	P-value
Age (yr)
≤ 60 vs > 60	1.023	0.740-1.414	0.889
Gender
Male vs female	0.692	0.474-1.009	0.056
Tumor size (cm)
≤ 5 vs > 5	0.987	0.704-1.386	0.942
Grade
G1 vs G2 and 3	1.498	1.060-2.116	0.022a	1.549	1.095-2.190	0.013a
Tumor location
Upper and middle vs lower	0.954	0.657-1.385	0.804
Depth of invasion
T2 vs T3	1.461	1.045-2.043	0.026a	1.493	1.066-2.089	0.020a
AJCC staging system (7th ed)
IB and IIA vs IIB	1.192	0.865-1.643	0.284
β-catenin
Low vs high	1.644	1.161-2.329	0.005b	1.642	1.159-2.327	0.005b

^aP < 0.05,

^bP < 0.01 vs univariate analysis.

AJCC: American Joint Committee on Cancer; CI: Confidence interval.