Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation

Figure 4 Inhibition of JAK/STAT signaling pathway: morphological alterations. Culture activated hepatic stellate cells were treated continually with AG490 throughout a five-day period and subsequently analyzed morphologically at days 1, 3 and 5. Cells treated with AG490 maintained their cytoplasmic projections (black arrows) throughout the five days of culture activation, whereas the control cells lost these processes as early as day 3.