Retransplantation for graft failure in chronic hepatitis C infection: A good use of a scarce resource?

Table 1 Comparison of peer-reviewed studies on retransplantation outcome in patients with hepatitis C virus infection

Author	Design	Number with HCV infection	Outcome	Predictors
Database studies
Rosen et al[11]	UNOS database	HCV total 357	54% 5-yr survival	HCV associated with mortality (HR 1.3)
Watt et al[12]	UNOS database	HCV total 899	45% 5-yr survival	MELD > 25
Petellier et al[13]	SRTR database	HCV total 464	NA	HCV associated with mortality (HR 1.3)
Ghabril et al[14]	UNOS database	HCV total 1034	rOLT 90 d-1 yr: 44% 3-yr survival	MELD > 25
			rOLT > 1 yr: 59% 3-yr survival	Donor > 60
				Donor black
				WIT > 75 min
Rowe et al, current study	UK Transplant database	34 recurrent HCV	Recurrent HCV rOLT 5-yr graft survival 45%	None
		46 HCV	HCV rOLT other reasons HCV 5-yr graft survival 80%
Center-led studies
Roayaie et al[15]	Retrospective single center	HCV total 42	52% alive at 6 mo	Donor < 60
				PT < 16 s
Neff et al[16]	Retrospective single center	HCV total 22	50% 1-yr survival	Normal physical activity
Carmiel-Haggai et al[17]	Retrospective single center	47 recurrent HCV	37% 1-yr mortality	Donor > 60
		62 HCV		Cirrhosis FCH
McCashland et al[18]	Prospective multicenter	HCV total 43	3-yr survival 49%	MELD not predictive
Bahra et al[19]	Retrospective single center	18 recurrent HCV	Recurrent HCV rOLT 5-yr survival 59%	MELD > 25
		11 HCV	HCV rOLT other reasons 5-yr survival 84%	Bilirubin > 15 mg/dL
Ghabril et al[10]	Retrospective single center	25 recurrent HCV	63% 3-yr survival	Donor age > 60
		48 HCV		Recipient > 60

UNOS: United Network for Organ Sharing; SRTR: Scientific registry of transplant recipients; HCV: Hepatitis C virus; rOLT: Retransplantation; MELD: Model for end-stage liver disease; PT: Prothrombin time; FCH: Fibrosing cholestatic hepatitis; WIT: Warm ischemia time.