Quality of life after laparoscopic and open colorectal surgery: A systematic review

Table 1 Overview of included trials

Author	Trial	QoL 1˚ or2˚ endpoint	No. of patients		Conversionrate (%)	Patients	Surgery	QoL measures	Timing of measures
			Lap	Open					Pre operative	Post operative
Janson et al[28]	Color	Primary	130	155	17.7	Colon cancer	Colon resection	EORTC-C30, EQ-5D	Yes	2, 4 and 12 wk
King et al[33,34]		Secondary	41	19	0.0	Colorectal cancer	Colorectal resection	EORTC-C30 and C38	Yes	2 and 6 wk
		Secondary	411	191						3, 6 and 12 mo
Guillou et al[4], Jayne et al[35]1	Classic	Secondary	526	268	29.0	Colorectal cancer	Colorectal resection	EORTC-C30 and C38	Yes	2 and 12 wk
		Secondary	6962							6, 18 and 36 mo
Braga et al[29]	Consort	Secondary	190	201	4.2	Colorectal cancer	Colorectal resection	SF-36	No	1, 2 and 4 yr
Weeks et al[30]	Cost	Primary	228	221	25.7	Colon cancer	Colon resection	QLI, SDS, Global QoL	Yes	2 d, 2 and 8 wk
Schwenk et al[31]		Primary	30	30	-	Colorectal cancer	Colorectal resection	EORTC-C30	Yes	1, 4 and 12 wk
Klarenbeek et al[1]	Sigma	Secondary	52	52	19.2	Diverticulitis	Sigmoid resection	SF-36	Yes	6 wk
Maartense et al[32], Eshuis et al[36]1		Primary	30	30	10.0	Crohn’s disease	Ileocolic resection	SF-36, GIQLI	Yes	1, 2, 4 and 12 wk
		Secondary	291	261						6.7 yr3
Maartense et al[2],		Primary	30	30	0.0	UC and FAP	RP & IPAA	SF-36, GIQLI	Yes	1, 2, 4 and 12 wk
Polle et al[37]1		Secondary	261	271						1 yr3

¹Long-term follow-up of same study population;

²Number of patients included in long term follow-up, data not specified for laparoscopic or open surgery;

³Median; -: No data available; RP & IPAA: Restorative proctocolectomy with ileo pouch anal anastomosis; QoL: Quality of life; UC: Ulcerative colitis; EORTC: European Organization for Research and Treatment of Cancer; SDS: Symptom Distress Scale; QLI: Quality of Life Index; GIQLI: Gastro Intestinal Quality of Life Index.