Staging of liver fibrosis in chronic hepatitis B patients with a composite predictive model: A comparative study

Table 3 Sensitivity, specificity, predictive values and likelihood ratios of scores according to different cutoffs for the diagnosis of significant fibrosis

Score	Cutoff	%	Significant fibrosis (F2-4)
			Sen	Spe	PPV	NPV	+LR	-LR
APRI	< 0.50	27	0.84	0.35	0.47	0.76	1.29	0.46
	> 1.50	32	0.47	0.80	0.62	0.69	2.35	0.66
FIB-4	< 1.45	65	0.63	0.85	0.74	0.76	4.20	0.44
	> 3.25	13	0.25	0.96	0.80	0.65	6.25	0.78
Forn’s index	< 4.20	46	0.75	0.63	0.59	0.78	2.03	0.40
	> 6.90	18	0.34	0.96	0.85	0.68	8.50	0.69
Hepascore	< 0.50	23	0.88	0.50	0.55	0.85	1.74	0.26
	> 0.84	27	0.50	0.91	0.80	0.72	5.56	0.55
SLFG	< 3.00	23	0.91	0.33	0.48	0.83	1.36	0.27
	> 8.70	22	0.47	0.96	0.88	0.72	11.75	0.55

Sen: Sensitivity; Spe: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; +LR: Positive likelihood ratio; -LR: Negative likelihood ratio.