Staging of liver fibrosis in chronic hepatitis B patients with a composite predictive model: A comparative study

Table 1 Main characteristics of patients studied

	Patients (n = 78)	F0F1 (n = 46)	F2F3F4 (n = 32)	P value (F0F1 vs F2F3F4)
Age (mean ± SD, yr)	32.6 ± 12.3	29.6 ± 12.0	36.9 ± 11.4	0.009
Men (n, %)	66 (84.6)	38 (82.6)	28 (87.5)	0.113
CHB family history (n, %)	29 (37.2)	18 (39.1)	11 (34.4)	0.104
WBC (mean ± SD, 109/L)	5.3 ± 1.4	5.5 ± 1.2	4.9 ± 1.6	0.060
Hb (mean ± SD, g/L)	142.6 ± 15.7	145.6 ± 13.4	138.3 ± 17.8	0.044
PLT (mean ± SD, 109/L)	170.2 ± 51.5	185.9 ± 40.7	147.6 ± 57.3	0.002
TB [median (interquartile range), μmol/L]	15.4 (11.5-20.6)	14.7 (10.6-19.1)	16.7 (12.1-24.1)	0.087
CB [median (interquartile range), μmol/L]	5.7 (4.0-7.8)	5.5 (3.9-7.1)	6.4 (4.5-10)	0.057
ALT [interquartile median (range), U/L]	115 (55-241)	93.5 (32-240)	132 (76-263)	0.165
AST [interquartile median (range), U/L]	67.5 (38-121)	56 (30-95)	86.5 (41-152)	0.042
GGT [interquartile median (range), U/L]	52.5 (27-76)	36.5 (21-59)	66.5 (46-94)	0.006
Alb (mean ± SD, g/L)	42.4 ± 5.1	44.0 ± 4.8	40.2 ± 4.6	0.001
PT (mean ± SD, s)	12.0 ± 1.1	11.5 ± 0.9	12.6 ± 0.9	< 0.001
PI (mean ± SD, s)	1.00 ± 0.08	1.03 ± 0.07	0.95 ± 0.06	< 0.001
TC (mean ± SD, mmol/L)	3.8 ± 0.8	3.8 ± 0.8	3.7 ± 0.9	0.135
HA [interquartile median (range), ng/mL]	125 (75-224)	88 (49-129)	167 (116-382)	< 0.001
A2M (mean ± SD, g/L)	2.96 ± 0.58	2.73 ± 0.48	3.28 ± 0.55	< 0.001
Lg HBV-DNA (mean ± SD)	6.0 ± 1.9	5.9 ± 2.0	6.1 ± 2.1	0.314
HBeAg positive (n, %)	55 (70.5)	32 (69.6)	23 (71.9)	0.223
Liver specimen length (mean ± SD, mm)	18.2 ± 3.4	18.4 ± 3.3	17.9 ± 3.6	0.254
METAVIR A stage (n, %)
A0	4 (5.1)
A1	41 (52.5)
A2	32 (41.1)
A3	1 (1.3)
METAVIR F stage (n, %)
F0	13 (16.7)
F1	33 (42.3)
F2	13 (16.7)
F3	10 (12.8)
F4	9 (11.5)

SD: Standard deviation; WBC: Leucocyte; Hb: Hemoglobin; TB: Total bilirubin; CB: Conjugated bilirubin; Alb: Albumin; TC: Total cholesterol.