Role of CYP2E1 gene polymorphisms association with hepatitis risk in Northeast India

Table 3 Detail distribution of Cytochrome P450 2E1 genotypes in different underlying etiology of hepatitis

	Number of individuals (% of group)			Less common allelefrequency	χ2value (P value)	OR (95% CI)
	Homozygous-more common allele	Heterozygous	Homozygous-less common allele
RsaI polymorphism	c1/c1	c1/c2	c2/c2
Controls (n = 124)	122 (98.4)	2 (1.6)	0	1.6	ref.
HAV (n = 38)	36 (94.7)	2 (5.3)	0	5.3	0.160	5.229 (0.840-32.537)
HBV (n = 22)	20 (90.9)	2 (9.1)	0	9.1	0.080	2.905 (0.252-33.484)
HCV (n = 4)	4 (100)	0 (0)	0	0	0.798	0.968 (0.938-1.0)
HEV (n = 10)	10 (100)	0 (0)	0	0	0.686	0.924 (0.880-0.971)
HAV + HBV (n = 2)	2 (100)	0 (0)	0	0	0.856	0.984 (0.962-1.006)
Alcoholic (n = 12)	8 (66.66)	4 (33.33)	0	33.33	< 0.0001	30.500 (4.835-192.418)
Cryptogenic (n = 16)	14 (87.5)	2 (12.5)	0	12.5	0.014	8.714 (1.137-66.784)
DraI polymorphism	DD	DC	CC
Controls (n = 124)	122 (98.4)	2 (1.6)	0	1.6	ref.
HAV (n = 38)	34 (89.5)	2 (5.25)	2 (5.25)	10.5	0.006	7.176 (1.260-40.863)
HBV (n = 22)	22 (100)	0	0	0	0.514	0.847 (0.790-0.908)
HCV (n = 4)	4 (100)	0	0	0	0.798	0.968 (0.938-1.0)
HEV (n = 10)	10 (100)	0	0	0	0.164	0.924 (0.880-0.971)
HAV + HBV (n = 2)	2 (100)	0	0	0	0.856	0.984 (0.962-1.006)
Alcoholic (n = 12)	10 (83.3)	2 (16.7)	0	16.7	0.003	12.220 (1.550-96.035)
Cryptogenic (n = 16)	14 (87.5)	0	2 (12.5)	12.5	0.014	8.714 (1.137-66.784)

Data represented as number of subjects showing respective genotype (%); P < 0.05 was considered to be statistically significant, control group was considered as reference group. HAV: Hepatitis A virus; HEV: Hepatitis E virus; HBV: Hepatitis B virus; HCV: Hepatitis C virus.