Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer

doi:10.3748/wjg.v16.i37.4738

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Oct 7, 2010 (publication date) through May 14, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2010; 16(37): 4738-4746
Published online Oct 7, 2010. doi: 10.3748/wjg.v16.i37.4738

Table 6 Interaction of SOD2 Val16Ala and environmental factors for gastric cancer development

Factors	SOD2	HC (%)	GC (%)	¹OR (95% CI)	β	γ = β_eg/β_e
Factors	SOD2	n = 147	n = 140	¹OR (95% CI)	β	γ = β_eg/β_e
Alcohol
No	Val/Val	89 (60.5)	33 (23.6)	1.00
No	Ala/-	11 (7.5)	21 (15.0)	4.89 (2.11-11.36)	1.59
Yes	Val/Val	34 (23.1)	52 (37.1)	5.26 (2.62-10.55)	1.66
Yes	Ala/-	13 (8.8)	34 (24.3)	9.46 (4.08-21.94)	2.25	1.36
Family history
Negative	Val/Val	114 (77.6)	58 (41.4)	1.00
Negative	Ala/-	21 (14.3)	41 (29.3)	3.90 (2.09-7.27)	1.36
Positive	Val/Val	9 (6.1)	27 (19.3)	6.34 (2.75-14.59)	1.85
Positive	Ala/-	3 (2.0)	14 (10.0)	12.86 (3.36-49.25)	2.55	1.38
Type I H. pylori
Negative	Val/Val	75 (51.0)	23 (16.4)	1.00
Negative	Ala/-	7 (4.8)	9 (6.4)	4.90 (1.59-15.08)	1.59
Positive	Val/Val	48 (32.7)	61 (43.6)	4.24 (2.30-7.09)	1.44
Positive	Ala/-	17 (11.6)	47 (33.6)	9.07 (4.36-18.86)	2.21	1.53

A/-: AA + AG; Ala/-: Ala/Val + Ala/Ala. ¹Adjusted for age, sex, OR, 95% CI, β were calculated by logistic regression. HC: Healthy control; GC: Gastric cancer.

Citation: Yi JF, Li YM, Liu T, He WT, Li X, Zhou WC, Kang SL, Zeng XT, Zhang JQ. Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer. World J Gastroenterol 2010; 16(37): 4738-4746
URL: https://www.wjgnet.com/1007-9327/full/v16/i37/4738.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i37.4738