Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer

doi:10.3748/wjg.v16.i37.4738

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Oct 7, 2010 (publication date) through Sep 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2010; 16(37): 4738-4746
Published online Oct 7, 2010. doi: 10.3748/wjg.v16.i37.4738

Table 4 Interaction of family history and SOD2 Val16Ala for malignant potential of gastric precancerous lesion

Family history	SOD2	GPL (%)	GC (%)	¹OR(95% CI)	β	γ = β_eg/β_e
Family history	SOD2	n = 145	n = 140	¹OR(95% CI)	β	γ = β_eg/β_e
Negative	Val/Val	89 (61.4)	58 (41.4)	1.00
Negative	Ala/-	31 (21.4)	41 (29.3)	2.22 (1.24-3.97)	0.80
Positive	Val/Val	24 (16.6)	27 (19.3)	1.99 (1.03-3.84)	0.69
Positive	Ala/-	1 (0.7)	14 (10.0)	7.71 (2.10-28.22)	2.04	2.96

A/-: AA + AG; Ala/-: Ala/Val + Ala/Ala. β: Regressive coefficient; γ: Interaction coefficients; β_eg: Regressive coefficient when genetic and environmental factors coexist; β_e: Regressive coefficient when environmental factors exist alone. ¹Adjusted for age, sex, OR, 95% CI, β were calculated by logistic regression. GPL: Gastric precancerous lesion; GC: Gastric cancer.

Citation: Yi JF, Li YM, Liu T, He WT, Li X, Zhou WC, Kang SL, Zeng XT, Zhang JQ. Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer. World J Gastroenterol 2010; 16(37): 4738-4746
URL: https://www.wjgnet.com/1007-9327/full/v16/i37/4738.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i37.4738