Prospective study of MMP7 serum levels in the diagnosis of cholangiocarcinoma

doi:10.3748/wjg.v16.i37.4697

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Oct 7, 2010 (publication date) through Dec 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2010; 16(37): 4697-4703
Published online Oct 7, 2010. doi: 10.3748/wjg.v16.i37.4697

Table 2 Performance of the biomarkers for the diagnosis of cholangiocarcinoma (%) (95% CI)

Tumor markers (cut-off value)	Sensitivity	Specificity	PPV	NPV	LR+	LR-
MMP7 (5.5 ng/mL)	75 (63-86)	78 (71-85)	61 (50-72)	87 (81-93)	3.41 (2.38-4.89)	0.33 (0.21-0.51)
MMP7 (6.5 ng/mL)	63 (50-75)	87 (81-93)	69 (56-81)	83 (77-90)	4.72 (2.91-7.66)	0.43 (0.31-0.60)
MMP7 (7.5 ng/mL)	53 (40-65)	92 (88-97)	76 (62-89)	81 (74-87)	6.73 (3.54-12.70)	0.51 (0.39-0.68)
CA19-9 (35 U/mL)	71 (60-83)	73 (66-81)	55 (44-66)	85 (78-91)	2.68 (1.93-3.73)	0.39 (0.26-0.59)
CA19-9 (100 U/mL)	68 (56-80)	87 (81-93)	70 (58-82)	85 (79-91)	5.1 (3.17-8.22)	0.37 (0.25-0.54)
CA19-9 (200 U/mL)	59 (47-72)	93 (89-97)	80 (68-91)	83 (77-89)	8.44 (4.34-16.40)	0.44 (0.32-0.60)

PPV: Positive predictive value; NPV: Negative predictive value; LR+: Positive likelihood ratio; LR-: Negative likelihood ratio; CI: Confidence interval; MMP7: Matrix metalloproteinase-7; CA19-9: Carbohydrate antigen 19-9.

Citation: Leelawat K, Narong S, Wannaprasert J, Ratanashu-ek T. Prospective study of MMP7 serum levels in the diagnosis of cholangiocarcinoma. World J Gastroenterol 2010; 16(37): 4697-4703
URL: https://www.wjgnet.com/1007-9327/full/v16/i37/4697.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i37.4697