Lowered HGK expression inhibits cell invasion and adhesion in hepatocellular carcinoma cell line HepG2

Figure 4 Down-regulation of hepatocyte progenitor kinase-like kinase inhibits HepG2 cell invasion. A: HepG2 cell invasiveness was significantly suppressed by retrovirus mediating RNAi targeting of hepatocyte progenitor kinase-like kinase (RV-shHGK)-1 vs RV-shHGK-C group (original magnification × 200, ^aP < 0.05); B: The blue-stained cells are those invading the ECMatrix and migrating through the polycarbonate membrane to the lower surface of the membrane (original magnification × 200, ^aP < 0.05 vs HepG2 cells infected with RV-shHGK-C); C: HepG2 cells infected with RV-shHGK-1 do not form the structure patterned network of interconnected loops (original magnification × 200).