A predictive factor for the response to S-1 plus cisplatin in gastric cancer

Table 4 Correlation between changes of protein expression of thymidylate synthase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase and responses (ng/mg protein)

	1st evaluation	2nd evaluation	Paired t-test
Responder(1st evaluation) → responder (2nd evaluation) (n = 2)
TS	30.0 ± 2.8	19.2 ± 2.3	NS
DPD	161.7 ± 53.3	172.6 ± 22.8	NS
OPRT	9.8 ± 0.6	4.7 ± 1.7	NS
Responder(1st evaluation) → non-responder(2nd evaluation) (n = 3)
TS	31.7 ± 4.6	53.9 ± 3.9	P < 0.01
DPD	204.4 ± 119.5	279.1 ± 124.7	P < 0.05
OPRT	4.3 ± 3.1	5.3 ± 1.3	NS
Non-responder(1st evaluation) → non-responder (2nd evaluation) (n = 2)
TS	73.4 ± 10.7	77.3 ± 45.4	NS
DPD	142.3 ± 52.6	247.5 ± 60.5	P < 0.05
OPRT	5.9 ± 1.3	8.4 ± 1.9	NS

TS: Thymidylate synthase; DPD: Dihydropyrimidine dehydrogenase; OPRT: Orotate phosphoribosyl transferase; NS: Not significant.