Liver disease and erythropoietic protoporphyria: A concise review

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Sep 28, 2010 (publication date) through Nov 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2010; 16(36): 4526-4531
Published online Sep 28, 2010. doi: 10.3748/wjg.v16.i36.4526

Table 1 Pathogenic mechanisms and therapeutic approaches of erythropoietic protoporphyria

Pathogenic mechanism	Treatment
Induce bile flow	Ursodeoxycholic acid
Reduce protoporphyrin production	Parenteral iron
	Transfusion of erythrocytes
	Infusions of hematin
Reduce protoporphyrin levels	Plasmapheresis
Reduce protoporphyrin levels	Extracorporeal albumin dialysis
Interrupt enterohepatic circulation	Cholestyramine
Interrupt enterohepatic circulation	Activated charcoal
Protect hepatocytes from toxic damage	N-acetyl cysteine
Remove the principal source of protoporphyrin	Bone marrow transplant
Erythropoietic protoporphyria-related liver failure	Liver transplant

Citation: Casanova-González MJ, Trapero-Marugán M, Jones EA, Moreno-Otero R. Liver disease and erythropoietic protoporphyria: A concise review. World J Gastroenterol 2010; 16(36): 4526-4531
URL: https://www.wjgnet.com/1007-9327/full/v16/i36/4526.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i36.4526