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World J Gastroenterol. Sep 28, 2010; 16(36): 4504-4514
Published online Sep 28, 2010. doi: 10.3748/wjg.v16.i36.4504
Published online Sep 28, 2010. doi: 10.3748/wjg.v16.i36.4504
Table 3 Clinical studies on plants used in traditional Iranian medicine for the treatment of inflammatory bowel disease
Study | Study design | No. of patients | Disease | Plant | Part of plant | Control group | Duration of treatment | Result |
Kaliora et al[82] | Open, comparing CD patients with healthy volunteers | 10 patients and 8 controls | CD | Pistacia lentiscus | Oleogum resin | - | 4 wk | ↓TNF-α secretion, ↑macrophage migration inhibitory factor release meaning that random migration and chemotaxis of monocytes/macrophages was inhibited |
Kaliora et al[83] | Open, comparing CD patients with healthy volunteers | 10 patients and 8 controls | CD | Pistacia lentiscus | Oleogum resin | - | 4 wk | Significant reduction of CD Activity Index, ↓Plasma IL-6 and C-reactive protein, ↑total antioxidant potential, no side effects observed |
Madisch et al[84] | Double-blind, randomized, placebo-controlled, multicenter | 31 | Collagenous colitis | Boswellia serrata | Gum resin extract | Placebo | 6 wk | The proportion of patients in clinical remission was higher in the Boswellia serrata extract group than in the placebo group; Compared to placebo, Boswellia serrata extract treatment had no effect on histology and quality of life |
Gupta et al[85] | Randomized | 30 | Chronic colitis | Boswellia serrata | Gum resin | Sulfasalazine | 6 wk | Eighteen out of 20 patients treated with Boswellia gum resin showed an improvement in one or more of the parameters including stool properties, histopathology as well as scanning electron microscopy, hemoglobin, serum iron, calcium, phosphorus, proteins, total leukocytes and eosinophils; In the sulfasalazine group, 6 out of 10 patients showed similar results in the same parameters, 14 out of 20 patients treated with Boswellia gum resin achieved remission, while in the case of sulfasalazine the remission rate was 4 out of 10 |
Gupta et al[86] | Randomized | 30 | UC | Boswellia serrata | Gum resin | Sulfasalazine | 6 wk | All tested parameters including stool properties, histopathology, scanning microscopy of rectal biopsies, and blood parameters including hemoglobin, serum iron, calcium, phosphorus, proteins, total leukocytes and eosinophils improved after treatment with Boswellia serrata gum resin. The rate of remission was similar in the two studies group (82% in the Boswellia serrata group vs 75% in the sulfasalazine group) |
Al-Habbal et al[87] | Double-blind controlled | 38 | Duodenal ulcer | Pistacia lentiscus | Oleogumresin | Placebo | 2 wk | Symptomatic relief in 80% of patients on oleogum resin from P. lentiscus and 50% in patients on placebo, endoscopically proven healing occurred in 70% of patients on oleogum resin from P. lentiscus and 22% of patients on placebo, no side effects observed |
Fernández-Bañares et al[88] | Open label, multicenter, randomized | 92 | UC | Plantago ovata | Seed | Mesalamine | 12 mo | 40% relapse rate in the P. ovata seed group and 35% in the mesalamine group and 30% in the Plantago ovata plus mesalamine group |
- Citation: Rahimi R, Shams-Ardekani MR, Abdollahi M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol 2010; 16(36): 4504-4514
- URL: https://www.wjgnet.com/1007-9327/full/v16/i36/4504.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i36.4504