Paeonol inhibits tumor growth in gastric cancer in vitro and in vivo

Figure 4 Expression of Bcl-2 and Bax in mouse forestomach carcinoma and SGC-7901 cells with or without paeonol treatment (× 200). A: SGC-7901, cells were treated with 62.5 mg/L paeonol or with vehicle control for 48 h. a: Untreated control; b: Paeonol treatment. Bax expression was detected by immunohistochemical analysis. Cells treated with paeonol had a significant increase in the expression of Bax. c: Untreated control; d: Paeonol treatment. Bcl-2 expression was detected by immunohistochemical analysis. Cells treated with paeonol had a significant decrease in the expression of Bcl-2; B: Mouse forestomach carcinoma, cells were treated with 62.5 mg/L paeonol or with vehicle control for 48 h. a: Untreated control; b: Paeonol treatment. Bax expression was detected by immunohistochemical analysis. Cells treated with paeonol had a significant increase in the expression of Bax. c: Untreated control; d: Paeonol treatment. Bcl-2 expression was detected by immunohistochemical analysis. Cells treated with paeonol had a significant decrease in the expression of Bcl-2.