Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: A meta-analysis

Table 4 Risk of esophageal cancer associated with alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 polymorphisms according to ethnicity or sex

ADH1B	ADH1B*1/*1 vs *2/*2pooled OR (95% CI)	P for heterogeneity	ALDH2	ALDH2*1/*2 vs *1/*1 pooled OR (95% CI)	P for heterogeneity
Ethnicity
Chinese (Mainland)
Never/rare drinkers[17,22]	1.20 (0.54-2.66)	0.81	Never/rare drinkers[17,22]	1.75 (1.14-2.70)	0.06
Moderate drinkers[17,22]	1.86 (0.52-6.60)	0.22	Moderate drinkers[17,22]	1.98 (1.20-3.27)	0.34
Heavy drinkers[22]	3.55 (1.01-11.83)	-	Heavy drinkers[22]	1.31 (0.54-3.12)	-
Chinese (Taiwan)
Never/rare drinkers[18,26]	2.15 (0.99-4.69)	0.51	Never/rare drinkers[18,26]	1.14 (0.42-3.07)	-
Moderate drinkers[26]	3.93 (2.00-7.74)	-	Moderate drinkers[26]	6.21 (3.78-10.22)	0.67
Heavy drinkers[18,26]	3.36 (1.73-6.53)	0.3	Heavy drinkers[18,26]	9.21 (5.54-15.31)	0.76
Japanese
Never/rare drinkers[15,21,24]	2.41 (0.50-11.62)	0.31	Never/rare drinkers[15,21,24,30]	0.68 (0.33-1.42)	0.55
Moderate drinkers[15,21,24]	2.18 (0.38-12.23)	0.05	Moderate drinkers[15,21,24]	4.74 (3.29-6.83)	0.4
Heavy drinkers[15,21,23,24]	4.02 (1.83-8.80)	0.64	Heavy drinkers[15,21,23,24,32,33]	9.75 (7.34-12.97)	0.69
Sex
Male
Never/rare drinkers[17,21,22,24,26]	2.71 (1.13-6.51)	0.24	Never/rare drinkers[17,21,22,24,26]	1.92 (1.28-2.88)	0.55
Moderate drinkers[17,21,22,24,26]	3.93 (2.43-6.36)	0.39	Moderate drinkers[17,21,22,24,26]	3.53 (1.98-6.30)	< 0.05
Heavy drinkers[21-24,26]	3.22 (2.16-4.83)	0.39	Heavy drinkers[21-24,26,32,33]	7.04 (4.18-11.85)	< 0.05
Female
Never/rare drinkers[21,22,33]	1.48 (0.56-3.49)	0.17	Never/rare drinkers[21,22,33]	1.55 (0.50-14.78)	0.03
Moderate drinkers[21,22,33]	0.81 (0.21-3.15)	0.41	Moderate drinkers[21,22,33]	2.64 (1.24-5.68)	0.72
Heavy drinkers[22]	3.55 (1.06-11.84)	0.35	Heavy drinkers[21,33]	6.85 (1.04-44.95)	0.88

ALDH2: Aldehyde dehydrogenase-2; ADH1B: Alcohol dehydrogenase-1B; OR: Odds ratio; CI: Confidence interval.