Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: A meta-analysis

Table 3 Risk of esophageal cancer associated with combinations of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes

Genotype	ALDH2 *1/*1 pooled OR (95% CI)	P for heterogeneity	ALDH2 *1/*2 pooled OR (95% CI)	P for heterogeneity
ADH1B *2/*2 or *1/*2
Never/rare drinkers[21,22]	1.00 (reference)	-	1.99 (0.53-7.5)	0.28
Moderate drinkers[21,22,26]	1.00 (reference)	-	5.64 (3.74-8.5)	0.68
Heavy drinkers[21-23,26]	1.00 (reference)	-	7.56 (3.4-16.78)	0.86
ADH1B *1/*1
Never/rare drinkers[21,22]	1.13 (0.22-5.7)	< 0.05	1.36 (0.41-4.51)	< 0.05
Moderate drinkers[21,22,26]	2.37 (1.13-4.97)	< 0.05	9.17 (0.6-140.38)	0.06
Heavy drinkers[21-23,26]	2.43 (1.48-3.99)	0.08	12.45 (2.9-53.46)	0.08

ALDH2: Aldehyde dehydrogenase-2; ADH1B: Alcohol dehydrogenase-1B; OR: Odds ratio; CI: Confidence interval.