Non-alcoholic steatohepatitis and influence of age and gender on histopathologic findings

Table 3 Histopathologic characteristics of non-alcoholic steatohepatitis patients regarding different sex and age groups (mean ± SD) n (%)

Finding	Total (n = 77)	Sex groups		P-value	Age groups		P-value
		Male (n = 58)	Female (n = 19)		< 55 yr (n = 65)	≥ 55 yr (n = 12)
Hepatosteatosis
Grade I	36 (46.8)	30 (51.7)	6 (31.6)		34 (54)	1 (11.2)
Grade II	29 (37.7)	22 (37.9)	7 (36.8)	0.068	23 (36.5)	4 (44.4)	0.007a
Grade III	12 (15.6)	6 (10.3)	6 (31.6)		6 (9.5)	4 (44.4)
Mean grade	1.69 ± 0.73	1.59 ± 0.68	2.00 ± 0.82	0.031a	1.56 ± 0.67	2.33 ± 0.71	0.002a
Fibrosis
No fibrosis	31 (41.3)	24 (42.1)	7 (38.9)		27 (44.3)	2 (22.2)
Grade I	29 (38.7)	24 (42.1)	5 (27.8)		22 (36.1)	4 (44.4)
Grade II	7 (9.3)	4 (7)	3 (16.7)	0.563	6 (9.8)	1 (11.1)	0.307
Grade III	3 (4)	2 (3.5)	1 (5.6)		3 (4.9)	-
Cirrhosis	5 (6.7)	3 (5.3)	2 (11.1)		3 (4.9)	2 (22.2)
Mean grade	0.96 ± 1.13	0.88 ± 1.05	1.22 ± 1.35	0.263	0.91 ± 1.09	1.56 ± 1.51	0.115
Hepatocyte ballooning
No ballooning	52 (72.2)	41 (74.5)	11 (64.7)		42 (71.2)	6 (75)
Grade I	12 (16.7)	8 (14.5)	4 (23.5)	0.224	11 (18.6)	1 (12.5)	0.935
Grade II	7 (9.7)	6 (10.9)	1 (5.9)		5 (8.5)	1 (12.5)
Grade III	1 (1.4)	-	1 (5.9)		1 (1.7)	-
Mean grade	0.40 ± 0.72	0.36 ± 0.68	0.53 ± 0.87	0.448	0.41 ± 0.72	0.37 ± 0.74	0.864
Lobar inflammation
No change	25 (36.8)	23 (42.6)	2 (14.3)		18 (31.6)	6 (100)
Grade I	37 (54.4)	27 (50)	10 (71.4)	0.138	34 (59.6)	-	0.005a
Grade II	6 (8.8)	4 (7.4)	2 (14.3)		5 (8.8)	-
Mean grade	0.72 ± 0.62	0.65 ± 0.62	1.00 ± 0.55	0.052	0.77 ± 0.60	-	0.004a
Portal inflammation
No change	41 (55.3)	33 (58.9)	8 (44.4)		35 (58.3)	3 (33.3)
Grade I	25 (33.8)	19 (33.9)	6 (33.3)		19 (31.7)	5 (55.6)	0.045a
Grade II	6 (8.1)	3 (5.4)	3 (16.7)	0.192	5 (8.3)	-
Grade III	2 (2.8)	1 (1.8)	1 (5.6)		1 (1.7)	1 (11.1)
Mean grade	0.59 ± 0.81	0.52 ± 0.76	0.83 ± 0.92	0.163	0.55 ± 0.79	0.89 ± 0.93	0.200

^aStatistically significant.