Non-alcoholic steatohepatitis and influence of age and gender on histopathologic findings

Table 2 Baseline and clinical characteristics of non-alcoholic steatohepatitis patients regarding different sex and age groups (mean ± SD)

Variable	Total (n = 77)	Sex groups		P-value	Age groups		P-value
		Male (n = 58)	Female (n = 19)		< 55 yr (n = 65)	≥ 55 yr (n = 12)
Age (yr)	41.99 ± 11.80	39.74 ± 10.16	48.72 ± 13.99	0.004a	-	-	-
Gender, n (%)
Female	19 (24.7)	-	-	-	14 (21.5)	5 (41.6)	0.214
Male	58 (75.3)				51 (78.5)	7 (58.4)
BMI (kg/m2)	28.62 ± 3.42	28.86 ± 3.25	27.81 ± 4.00	0.336	28.74 ± 3.55	26.87 ± 2.52	0.186
Fasting blood sugar (mg/dL)	107.37 ± 47.60	103.16 ± 47.39	121.14 ± 47.14	0.195	107.88 ± 52.06	114.12 ± 25.85	0.742
Total cholesterol (mg/dL)	197.29 ± 47.81	192.07 ± 45.52	212.68 ± 52.26	0.105	197.07 ± 46.98	200.67 ± 37.82	0.827
Triglyceride (mg/dL)	202.26 ± 118.13	201.72 ± 97.26	203.89 ± 169.65	0.947	206.40 ± 121.92	202.33 ± 100.36	0.876
LDL-cholesterol (mg/dL)	119.09 ± 39.20	119.87 ± 35.00	117.13 ± 49.64	0.822	118.27 ± 38.74	134.43 ± 40.13	0.313
HDL-cholesterol (mg/dL)	46.61 ± 24.53	44.97 ± 25.20	50.87 ± 22.97	0.301	47.86 ± 26.45	40.12 ± 13.68	0.891
PTT (s)	12.47 ± 1.50	12.39 ± 1.66	12.72 ± 0.86	0.846	12.45 ± 1.58	12.40 ± 1.52	0.842
Platelet count (/L)	358 505 ± 48 852	357 505 ± 52 403	361 125 ± 39 954	0.122	395 325 ± 55 385	237 385 ± 63 753	0.964
ALT (U/L)	117.73 ± 237.52	92.05 ± 60.72	196.11 ± 466.82	0.943	123.21 ± 260.49	100.44 ± 91.57	0.772
AST (U/L)	58.29 ± 27.77	52.78 ± 25.00	75.11 ± 29.68	0.002a	57.28 ± 28.17	57.89 ± 20.52	0.951
Alk-P (U/L)	176.48 ± 96.95	171.14 ± 92.19	192.21 ± 111.00	0.417	176.11 ± 94.50	183.44 ± 128.40	0.837
γ-GTP (U/L)	29.55 ± 28.40	28.69 ± 30.95	31.42 ± 24.47	0.852	28.74 ± 3.55	15.17 ± 3.76	0.333

^aStatistically significant. BMI: Body mass index; LDL: Low density lipoprotein; HDL: High density lipoprotein; PTT: Partial thromboplastin time; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; Alk-P: Alkaline phosphatase; γ-GTP: γ-glutamyl transpeptidase.