Lymphangiogenesis: A new player in cancer progression

Figure 1 Lymphangiogenic growth factors and their receptors expressed by lymphatic endothelium. Vascular endothelial growth factor (VEGF) receptor (VEGFR)-3 is a member of the fms-like tyrosine kinase family and specifically binds VEGF-C and VEGF-D, but not VEGF-A. Recent studies also indicate an important role for the VEGF-A/VEGFR-2 signaling pathway in lymphangiogenesis.