Serological diagnostic factors for liver metastasis in patients with colorectal cancer

Table 5 Screening test for liver metastasis in patients with colorectal cancer

	Sen (%)	Spe (%)	DI	CA	AA	PV+	PV-	P	α	β
LDH	64.3	64.0	1.283	0.642	0.641	0.667	0.615	0.003	0.360	0.356
GGT	69.6	60.0	1.296	0.651	0.649	0.661	0.638	0.001	0.400	0.304
CEA	70.4	52.4	1.228	0.625	0.623	0.655	0.579	0.039	0.476	0.296
LDH and CEA (serial test)	51.9	85.7	1.376	0.667	0.695	0.823	0.581	0.007	0.143	0.481
LDH and CEA (parallel test)	85.2	42.9	1.281	0.667	0.657	0.657	0.692	0.030	0.571	0.148
GGT and CEA (serial test)	44.4	85.7	1.301	0.625	0.662	0.800	0.545	0.025	0.143	0.556
GGT and CEA (parallel test)	92.6	38.1	1.307	0.687	0.691	0.658	0.800	0.009	0.619	0.074

LDH: Lactate dehydrogenase; GGT: γ-glutamyltransferase; CEA: Carcinoembryonic antigen; Sen: Sensitivity; Spe: Specificity; DI: Diagnostic index; α: False positive rate; β: False negative rate; CA: Crude accuracy; PV+: Positive predictive value; PV-: Negative predictive value.