Anti-proliferative and pro-apoptotic effects of tectorigenin on hepatic stellate cells

doi:10.3748/wjg.v16.i31.3911

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Aug 21, 2010 (publication date) through Nov 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2010; 16(31): 3911-3918
Published online Aug 21, 2010. doi: 10.3748/wjg.v16.i31.3911

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Figure 10 Tectorigenin produces reactive oxygen species and increases Ca²⁺ concentration in cytoplasm of hepatic stellate cells-T6 cells, leading to the depletion of mitochondrial membrane potential and release of cytochrome c from mitochondria. Cytochrome c facilitates apoptosis of hepatic stellate cells-T6 cells by activating caspase cascade. ROS: Reactive oxygen species.

Citation: Wu JH, Wang YR, Huang WY, Tan RX. Anti-proliferative and pro-apoptotic effects of tectorigenin on hepatic stellate cells. World J Gastroenterol 2010; 16(31): 3911-3918
URL: https://www.wjgnet.com/1007-9327/full/v16/i31/3911.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i31.3911