Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients

Figure 1 Most frequently occurring NR3C1 haplotypes and their single nucleotide polymorphisms composition. The localization of the variant nucleotides in the N3RC1 gene is indicated. All detected non-synonymous single nucleotide polymorphism (SNP) (R23K, A229T, N363S) flank the N-terminal transactivation domain. Only four out of 17 predicted haplotypes occur at a frequency higher than 2%.