Expression of protein S100A4 is a predictor of recurrence in colorectal cancer

doi:10.3748/wjg.v16.i31.3897

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2010; 16(31): 3897-3904
Published online Aug 21, 2010. doi: 10.3748/wjg.v16.i31.3897

Table 1 Relationship between expression of protein S100A4, E-cadherin, p53 and clinicopathologic parameters n (%)

Parameters	Expression of protein S100A4			Expression of E-cadherin			Expression of p53
	Negative	Positive	P value	Reduced	Preserved	P value	Negative	Positive	P value
	(n = 82)	(n = 45)	P value	(n = 48)	(n = 79)	P value	(n = 56)	(n = 71)	P value
Gender			0.465			0.787			0.364
Male	51 (62.2)	25 (55.6)		28 (58.3)	48 (60.8)		36 (64.3)	40 (56.3)
Female	31 (37.8)	20 (44.4)		20 (41.7)	31 (39.2)		20 (35.7)	31 (43.7)
Age (yr)			0.797			0.963			0.344
mean ± SD	58.4 ± 11.1	60.9 ± 11.2	0.797	59.3 ± 13.1	59.4 ± 10.0	0.963	58.3 ± 9.6	60.2 ± 12.3	0.344
Tumor location			0.352			0.120			0.528
Colon	38 (46.3)	17 (37.8)		25 (52.1)	30 (38.0)		26 (46.4)	29 (40.8)
Rectum	44 (53.7)	28 (62.2)		23 (47.9)	49 (62.0)		30 (53.6)	42 (59.2)
Differentiation			0.500¹			0.001¹			0.695
Differentiated	75 (91.5)	42 (93.3)		39 (81.3)	78 (98.7)		51 (91.1)	66 (93.0)
Undifferentiated	7 (8.5)	3 (6.7)		9 (18.8)	1 (1.3)		5 (8.9)	5 (7.0)
Depth of tumor			0.319			0.615			0.154
T1-2	25 (30.5)	10 (22.2)		12 (25.0)	23 (29.1)		19 (33.9)	16 (22.5)
T3-4	57 (69.5)	35 (77.8)		36 (75.0)	56 (70.9)		37 (66.1)	55 (77.5)
Lymph node metastasis			0.282			0.338			0.667
Absent	50 (61.0)	23 (51.1)		25 (52.1)	48 (60.8)		31 (55.4)	42 (59.2)
Present	32 (39.0)	22 (48.9)		23 (47.9)	31 (39.2)		25 (44.6)	29 (40.8)
Distant metastasis			0.053¹			0.365¹			0.654¹
Absent	81 (98.8)	41 (91.1)		45 (93.8)	77 (97.5)		53 (94.6)	69 (97.2)
Present	1 (1.2)	4 (8.9)		3 (6.3)	2 (2.5)		3 (5.4)	2 (2.8)
pTNM stage			0.175			0.403			0.857
I	17 (20.7)	7 (15.6)		6 (12.5)	18 (22.8)		11 (19.6)	13 (18.3)
II	33 (40.2)	16 (35.6)		19 (39.6)	30 (38.0)		20 (35.7)	29 (40.8)
III	31 (37.8)	18 (40.0)		20 (41.7)	29 (36.7)		22 (39.3)	27 (38.0)
IV	1 (1.2)	4 (8.9)		3 (6.3)	2 (2.5)		3 (5.4)	2 (2.8)
Recurrence²			0.004			0.269			0.845
Absent	67 (82.7)	24 (58.5)		31 (68.9)	60 (77.9)		40 (75.5)	51 (73.9)
Present	14 (17.3)	17 (41.5)		14 (31.1)	17 (22.1)		13 (24.5)	18 (26.1)

¹Calculated by Fisher’s exact test; ²Stage IV patients were excluded.

Citation: Kwak JM, Lee HJ, Kim SH, Kim HK, Mok YJ, Park YT, Choi JS, Moon HY. Expression of protein S100A4 is a predictor of recurrence in colorectal cancer. World J Gastroenterol 2010; 16(31): 3897-3904
URL: https://www.wjgnet.com/1007-9327/full/v16/i31/3897.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i31.3897