First-line eradication of Helicobacter pylori: Are the standard triple therapies obsolete? A different perspective

Table 1 Topics of meta-analyses of Helicobacter pylori eradication between 1992-2010

Topics of meta-analysis	No. of studies
First-line triple therapies	25
PPI-based therapies	22
Ranitidine bismuth citrate-based therapies	3
Bismuth-based quadruple therapies	2
Non-bismuth-based quadruple therapies	1
Histamine H2 receptor blockers + two different antibiotics	5
Rescue (second- and third-line) therapies	3
Sequential therapies	4
Alternative therapies	4
Eradication in functional dyspepsia	20
Eradication in peptic ulcer	10
Effect of CagA status on eradication	1
Gastric cancer prevention	5
Eradication in children	2
Eradication in prevention of NSAID-ulcers	1
Eradication in extradigestive diseases	5
Effect of probiotics on eradication results	5
Eradication and antimicrobial resistance	4
Effect of CYP polymorphism on eradication	2
Adverse effects of eradication	4
Multiple topics	11
Total	113

PPI: Proton pump inhibitors; NSAID: Nonsteroidal anti-inflammatory drugs; CYP: Cytochrome P450 isoenzyme.