Portal vein ligation accelerates tumor growth in ligated, but not contralateral lobes

Figure 7 Effect of portal vein ligation on tumor growth. A: CT26.WT cells were injected into portal the vein. Mice were sacrificed at 14 d after injection following sham operation or portal vein ligation (PVL) performed on day 7 after injection; B: Representative pictures of liver histology after PVL. Small metastatic foci were observed in sham-operated and non-ligated lobes. Large metastatic foci were observed in ligated lobes. Original magnification was 10 ×; C: The ratio of metastases to normal liver was measured by morphometry. Data are mean ± SE with n = 4 per group. ^aP < 0.05 vs sham-operated group and PVL-non-ligated group.