Neoadjuvant treatment of esophageal cancer

Table 5 Randomized controlled trials of perioperative chemotherapy vs surgery alone for esophageal cancer

Studies	Histology	Treatment	n	MS (mo)	5-yr OS (%)	P
Roth et al[67], 1988	AC/SCC	BVC	19	9	25	NS
		Surgery	20	9	5
Kelsen et al[32], 1998	AC/SCC	CF	2131	15	19	NS
		Surgery	227	16	20
Cunningham et al[68], 2006	AC2	ECF	250	24	36	NS
		Surgery	253	20	23
Boige et al[69], 2007	AC3	CF	1134		38	< 0.05
		Surgery	111		24

¹Of 213 patients in the perioperative arm, only 66 later received adjuvant chemotherapy;

²26% had AC of the GEJ and lower esophagus;

³11% had esophageal AC;

⁴Of 113 patients in the perioperative arm, only 54 later received adjuvant chemotherapy. MS: Median survival; SCC: Squamous cell carcinoma; AC: Adenocarcinoma; B: Bleomycin; C: Cisplatin; V: Vindesine; F: Fluorouracil; E: Epirubicin; NS: Not significant; OS: Overall survival.