Neoadjuvant treatment of esophageal cancer

Table 4 Randomized controlled trials of neoadjuvant chemotherapy vs surgery alone for esophageal cancer

Studies	Histology	Treatment	n	MS (mo)	3-yr OS (%)	P
Schlag et al[57], 1992	SCC	CF	22	7		NS
		Surgery	24	6
Nygaard et al[51], 1992	SCC	BC	44	7	3	NS
		Surgery	41	7	9
Maipang et al[58], 1994	SCC	BVC	24	17	31	NS
		Surgery	22	17	36
Law et al[59], 1997	SCC	CF	74	17	40	NS
		Surgery	73	13	13
Kelsen et al[32], 1998	AC/SCC	CF	213	15	191	NS
		Surgery	227	16	201
Ancona et al[60], 2001	SCC	CF	47	25	341	NS
		Surgery	47	24	221
MRC[61], 2002	AC/SCC	CF	400	17	43	< 0.01
		Surgery	402	13	34

¹5-year OS. MS: Median survival; SCC: Squamous cell carcinoma; AC: Adenocarcinoma; C: Cisplatin; F: Fluorouracil; B: Bleomycin; V: Vindesine; NS: Not significant; OS: Overall survival.