Neoadjuvant treatment of esophageal cancer

Table 1 Randomized controlled trials of adjuvant radiotherapy vs surgery alone for esophageal cancer

Studies	Histology	Treatment	n	MS (mo)	5-yr OS (%)	P	RT dose (Gy)
Kunath et al[44], 1984	SCC	ART	23	9		NS	50-55
		Surgery	21	6
Ténière et al[45], 1991	SCC	ART	102	18	19	NS	45-55
		Surgery	119	18	19
Fok et al[36], 1993	SCC	ART	42	11	10	NS	43-53
		Surgery	39	22	16
Zieren et al[46], 1995	SCC	ART	33		231	NS	56
		Surgery	35		221
Xiao et al[47], 2003	AC/SCC	ART	220		41	NS	50-60
		Surgery	275		32

¹3-year OS. MS: Median survival; RT: Radiotherapy; SCC: Squamous cell carcinoma; AC: Adenocarcinoma; ART: Adjuvant radiotherapy; NS: Not significant; OS: Overall survival.