Non-peptidyl low molecular weight radical scavenger IAC attenuates DSS-induced colitis in rats

Figure 4 Effect of bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decandioate 30 mg/kg (hydrophilic or lipophilic form) on dextran sodium sulphate-induced colon weight loss (absolute value, A, and % inhibition, B) and shrinkage (absolute values, C, and % inhibition, D) in the different experimental groups. Six-day treatment with lipophilic bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decandioate (IAC) ip significantly inhibited colon weight loss and colon shrinkage induced by inflammation, while the hydrophilic form had no effect. Data are expressed as mean ± SE; n = 5-12 rats per group. ^aP < 0.05 vs water; ^dP < 0.01 vs dextran sodium sulphate (DSS). IAC hydro: Hydrophilic form of IAC; IAC lipo: Lipophilic form of IAC.