Non-peptidyl low molecular weight radical scavenger IAC attenuates DSS-induced colitis in rats

Figure 3 Effect of bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decandioate 30 mg/kg (hydrophilic or lipophilic form) on total macroscopic (A) and microscopic damage score (B) and on myeloperoxidase activity (C) in the different experimental groups. Treatment with hydrophilic bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decandioate (IAC) po decreased colonic microscopic damage but had no effect on macroscopic and myeloperoxidase (MPO) activity. Six-day treatment with lipophilic IAC po and ip significantly reduced intestinal damage induced by inflammation. Data are expressed as mean ± SE; n = 5-12 rats per group. ^aP < 0.05, ^bP < 0.01 vs dextran sodium sulphate (DSS); ^dP < 0.001 vs drinking water. ICC hydro: Hydrophilic form of IAC; IAC lipo: Lipophilic form of IAC.