Capecitabine with radiation is an effective adjuvant therapy in gastric cancers

Table 3 Recurrence-free survival and overall survival analysis

Variable	Categories/units	Chemo alone		5FU-RT		XRT
		HR (95% CI)	P-value1	HR (95% CI)	P-value1	HR (95% CI)	P-value1
Recurrence-free survival
ECOG	0	1	0.9	1	1.0	E/N = 0/1	0.5
	1	0.92 (0.115-7.422)		1.01 (0.238-4.326)		NE
Gender	Male	1	0.9	1	0.2	1	0.5
	Female	0.91 (0.244-3.419)		1.58 (0.727-3.436)		0.65 (0.198-2.163)
Surgical margins	Positive	1	0.5	1	< 0.001	1	0.03
	Negative	0.51 (0.059-4.351)		0.16 (0.070-0.384)		0.27 (0.081-0.918)
Stage	1 or 2	1	0.1	1	0.2	1	0.06
	3 or 4	2.92 (0.724-11.773)		1.86 (0.749-4.633)		3.87 (0.853-17.586)
Grade of tumor	1, 2	1	0.3	1	0.09	1	0.3
	3	2.17 (0.444-10.636)		2.44 (0.836-7.099)		1.94 (0.515-7.288)
Overall survival
ECOG	0	1	0.8	1	0.9	E/N = 0/1	0.4
	1	0.78 (0.096-6.366)		0.95 (0.220-4.069)		NE
Gender	Male	1	1.0	1	0.2	8/22	0.7
	Female	1.02 (0.253-4.148)		1.63 (0.740-3.598)		0.78 (0.234-2.597)
Surgical margins	Positive	1	0.004	1	< 0.001	4/4	0.02
	Negative	0.10 (0.013-0.700)		0.26 (0.113-0.603)		0.25 (0.071-0.901)
Stage	1 or 2	1	0.2	1	0.1	2/12	0.06
	3 or 4	2.59 (0.646-10.412)		2.08 (0.778-5.557)		3.80 (0.829-17.397)
Grade of tumor	1, 2	1	0.4	1	0.06	3/12	0.4
	3	2.04 (0.418-9.944)		3.04 (0.903-10.239)		1.83 (0.482-6.980)

¹P -values were calculated using the Log-rank test. 5FU-RT: 5-fluorouracil + radiation; XRT: Capecitabine + radiation; ECOG: Eastern Cooperative Oncology Group status; E/N: Number of events/number of patients in the group; NE: Not estimable; HR: Hazard ratio.