Protein-protein interaction map is a key gateway into liver regeneration

Figure 2 The classical and basic view of transforming growth factor β signaling pathway during liver regeneration. Generally speaking, transforming growth factor β (TGFβ) superfamily ligands bind to a type II receptor (RII), which recruits and phosphorylates a RI. The RI then phosphorylates receptor-regulated Smads. Then complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.