Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia

Table 3 Interaction between ALDH2 genotypes and environmental factors for esophageal dysplasia n (%)

Factors	Genotype	Controls	Cases	OR (95% CI)1	OR (95% CI)2
Smoking index	ALDH2
0	A/A	18 (8.5)	3 (1.6)	1.00	1.00
0	G/A	62 (29.2)	33 (17.9)	3.19 (0.88-11.64)	3.10 (0.84-11.45)
0	G/G	37 (17.5)	45 (24.5)	7.30 (1.99-26.71)	6.97 (1.88-25.87)
< 500	A/A	17 (8.0)	3 (1.6)	1.06 (0.19-5.99)	0.98 (0.17-5.77)
< 500	G/A	22 (10.4)	19 (10.3)	5.18 (1.32-20.35)	4.70 (1.16-19.07)
< 500	G/G	8 (3.8)	21 (11.4)	15.75 (3.63-68.41)	13.10 (2.85-62.14)
≥ 500	A/A	6 (2.8)	7 (3.8)	7.00 (1.36-36.01)	6.84 (1.25-37.36)
≥ 500	G/A	22 (10.4)	21 (11.4)	5.73 (1.47-22.33)	5.03 (1.21-20.82)
≥ 500	G/G	20 (9.4)	32 (17.4)	9.60 (2.50-36.81)	7.78 (1.92-31.53)
Drinking index	ALDH2
0	A/A	20 (9.4)	8 (4.3)	1.00	1.00
0	G/A	50 (23.6)	34 (18.5)	1.70 (0.67-4.30)	1.98 (0.75-5.25)
0	G/G	36 (17.0)	39 (21.2)	2.71 (1.06-6.91)	3.16 (1.19-8.41)
< 65	A/A	12 (5.7)	3 (1.6)	0.63 (0.14-2.82)	0.65 (0.19-3.09)
< 65	G/A	27 (12.7)	15 (8.2)	1.39 (0.48-3.91)	1.19 (0.40-3.50)
< 65	G/G	9 (4.2)	23 (12.5)	6.39 (2.07-19.69)	5.05 (1.57-16.15)
≥ 65	A/A	9 (4.2)	2 (1.1)	0.56 (0.10-3.16)	0.43 (0.07-2.52)
≥ 65	G/A	29 (13.7)	24 (13.0)	2.07 (0.78-5.23)	1.70 (0.60-4.80)
≥ 65	G/G	20 (9.4)	36 (19.6)	4.50 (1.68-12.06)	3.19 (1.12-9.28)
History of esophageal cancer	ALDH2
No	A/A	31 (15.8)	10 (5.4)	1.00	1.00
No	G/A	82 (41.8)	61 (33.2)	2.31 (1.05-5.06)	2.23 (1.01-4.93)
No	G/G	53 (27.0)	81 (44.0)	47.74 (2.15-10.47)	4.30 (1.93-9.62)
Yes	A/A	9 (4.6)	3 (1.6)	1.03 (0.23-4.58)	0.88 (0.20-4.01)
Yes	G/A	14 (7.1)	12 (6.5)	2.66 (0.93-7.59)	2.37 (0.82-6.89)
Yes	G/G	7 (3.6)	17 (9.2)	7.53 (2.42-23.37)	7.11 (2.25-22.45)

¹Crude OR;

²Adjusted ORs were adjusted for age and gender. OR: Odds ratio; CI: Confidence intervals.