Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia

Table 1 Characteristics of cases and controls n (%)

Variables	Controls	Cases	t/χ2	P3
Age (yr)	51.01 ± 8.427	54.89 ± 8.443	-4.567	0.000
Income (yuan/yr per person)	1825 ± 1605	1768 ± 1599	0.350	0.726
Height (cm)	163.71 ± 7.374	164.40 ± 7.225	-0.944	0.346
Weight (kg)	67.08 ± 52.848	61.36 ± 8.027	0.671	0.502
Body mass index (kg/m2)	23.08 ± 2.957	22.68 ± 2.462	1.470	0.142
SBP (mmHg)	132.45 ± 19.852	135.38 ± 20.411	-1.445	0.149
DBP (mmHg)	84.74 ± 13.083	85.27 ± 13.132	-0.406	0.685
Gender
Male	123 (58.0)	124 (67.4)	3.687	0.055
Female	89 (42.0)	60 (184)
Age (yr)
40-49	94 (44.3)	41 (22.3)	22.407	0.000
50-59	81 (38.2)	91 (49.5)
60-69	37 (17.5)	52 (28.3)
Education
Illiteracy	33 (15.6)	34 (18.5)	6.838	0.077
Primary school	54 (25.5)	54 (29.3)
High school	96 (45.3)	85 (46.2)
College and above	29 (13.7)	11 (6.0)
Smoking index1
0	117 (55.2)	81 (44.0)	6.107	0.047
< 500	47 (22.2)	43 (23.4)
≥ 500	48 (22.6)	60 (32.6)
Alcohol drinking status2
0	106 (50.0)	81 (44.0)	2.057	0.358
< 65	48 (22.6)	41 (22.3)
≥ 65	58 (27.4)	62 (33.7)
History of esophageal cancer
No	166 (84.7)	152 (82.6)	0.302	0.582
Yes	30 (15.3)	32 (17.4)
ALDH2
G/G	65 (30.7)	98 (53.3)	25.431	0.000
G/A	106 (50.0)	73 (39.7)
A/A	41 (19.3)	13 (7.1)

¹Smoking index = cigarettes/d × number of smoking years;

²Alcohol ≥ 65 g/d = heavy drinker;

³t test and χ² test were used for quantitative data variables and categorical data variables respectively. SBP: Systolic blood pressure; DBP: Diastolic blood pressure.